Mr. Doublemint used to tell us that using his gum would cause our Happiness Quotient to burst into a nova, which might be the ultimate case of gilding the lily. Until now. Mr. D. has presently been grossly upstaged by one Dario Amodei, an Artificial Intelligence company CEO, who tells us we’ll soon be able to double our lifespan. Nobody doubts that having AI churn through unfathomable amounts of data in search of useful therapies and maybe even cures is a logical notion. Whether processing information on cellular senescence, telomere shortening, cancer, mitochondrial dysfunction, genomic instability or a legion of other causes of aging and death, research has shown that AI will be an invaluable tool. But entrepreneur Amodei has bigger ideas.
What if Artificial Intelligence was more than a tool? What if, instead, it was the lead author of the next chapter in human longevity? The idea has led some technologists, most notably Amodei, wagonmaster of San Francisco-based goliath Anthropic, to the controversial conclusion that AI won’t just continue the longevity revolution, it will supercharge it.
“This might seem radical, but life expectancy increased almost 2x in the 20th century—from 40 years to 75—so it’s on trend that the ‘compressed 21st’ would double it again to 150,” Amodei wrote. “There already exist drugs that increase maximum lifespan in rats by 25-50% with limited ill effects. And some animals already live 200 years, so humans are manifestly not at some theoretical upper limit.”
Dario Amodie is not one to dawdle. At the 2025 World Economic Forum in Davos, Switzerland, he claimed that AI could double human lifespans in just five years, a mind-blowing timeline, but one he says is in line with AI development. And he’s not alone. Futurist Ray Kurzwell has stated that AI could push the pause button on aging as soon as 2032 in two ways. The first is through the use of AI-enabled medical nanobots that can repair damaged cells and deliver drugs directly to the affected region. The second is the ability to back up our brains to the cloud via AI, something much more dubious considering our limited knowledge of the human brain and how it works. Dario Amodie, of course, is a lesser-known new guy with a dog in this fight and Ray Kurzwell is a noted optimist. What does David Sinclair have to say?
The Sinclair Predictions
“The first person to live to 150 has already been born.”---D. Sinclair
David Sinclair, a Harvard University Medical School genetics professor and author of several books about aging believes that with current medical technology aided by Artificial Intelligence, startling upcoming breakthroughs are inevitable. “It’s realistic to believe the goal is realistic for people currently alive,” he states.
“The epigenome, the software that tells cells which genes to use, can be reset to a more youthful state. Partial cellular programming using a cocktail of molecules or gene therapy will be used to turn back the aging clock.”
Sinclair argues that instead of treating individual diseases like cancer or Alzheimer’s as they appear, we should focus on the underlying root cause of all of them, aging itself. He clarified that his goal is not just to extend the time one spends on Earth as a frail, elderly person, but to extend the healthy vital years. He imagines a world where 120-130 year olds are as active and healthy as 60 year olds are today. Sinclair’s trials for reversing aging are in their early stages right now.
If David Sinclair is the adult in the aging room, Bryan Johnson is the whiz kid teenager running around the house with ants in his pants. Johnson, a young 46, is the hottest longevity guru on the block with his $2 million a year Blueprint project to reverse aging and achieve a biological age of 18. The optimistic tech entrepreneur uses extreme data-driven methods to achieve his goal, one of which is to consume 111 supplements a day. He has a strict diet, constantly monitors his organs and even gets plasma donations from his son. All this has allowed him to reach (by his calculation) a biological age of 21. Unfortunately, instant replays of his achievement cannot be sent to SEC headquarters for verification.
Another contender for longevity guru of the decade is Peter Attia, a Canadian-American physician and author of Outlive: The Science & Art of Longevity, a runaway best seller. Attia is famous for his evidence-based podcasts and focus on healthspan and he has a booming clientele.
The Death-Defying All-Star Team
1. Elizabeth Bathory. Lizzie has the Guinness World Record as the most prolific female murderer ever, with 650 scalps on her belt. Nothing personal, though. The Hungarian countess really needed the bodies to replenish her bathtub, where she regularly bathed in the blood of her young victims to maintain her youth and beauty. Didn’t work. She was finally arrested in 1612 and confined to her castle, where she passed away at age 54. Nice try though, Liz.
2. Charles-Edouard Brown-Sequard. This Mauritian scientist gained notoriety for his unconventional methods and eccentric behavior in the world of hormone study. He is especially famous for the Brown-Sequard Elixir, which he claimed could make people look younger and live longer. Aging faster than he liked, Charlie began injecting himself with extracts from the testicles of guinea pigs and dogs, positing that these substances boosted his strength and enhanced his sexual performance. You could argue that he succeeded, living to age 76 when the life expectancy for a male born in 1817 was 30-40 years.
3. Peter Thiel. American billionaire Thiel has zeroed in on blood transfusions as a means to extend his life. With an estimated worth of $9 billion, Thiel reportedly aspires to live until he is 120 years old. He has invested heavily in anti-aging research since 2006 and admitted to ingesting human-growth hormone to maintain his bone and muscle health. Currently, Thiel is focusing on parabiosis, the scientific term for rejuvenating blood transfusions, but is hedging his bets by taking steps to cryogenically preserve his body just in case.
4. Howard Hughes. Howard had no magic amulets or wondrous elixirs, he was just hard to kill. Hughes was a daredevil in the public mind and an innovator within the aviation industry who became famous for his experimental and often controversial ideas concerning airplane design and performance. In May, 1943, he was practicing water landings in a Sikorsky amphibious aircraft and crashed heavily into Lake Mead, killing two of his passengers and sustaining severe injuries himself. Three years later, while flying the experimental XF-111 prototype reconnaissance plane, Hughes crashed again near the Los Angeles County Club, destroying three houses before exploding into flames. Howard managed to drag himself free of the plane despite suffering a crushed chest, which relocated his heart to the right side of his body; he also had several broken bones and severe burns. His doctors considered his recovery a miracle, but Hughes gave the credit to fresh-squeezed orange juice.
5. Doulas Bader. Bader was a somewhat reckless Royal Air Force pilot between the World Wars, known for undertaking aerobatic maneuvers which were both dangerous and forbidden. In 1932, during one such adventure, Bader crashed and the injuries he sustained were severe enough to cause surgeons to remove both of his legs, one above the knee, one below. After he recovered Dougie lobbied to be returned to flying status, arguing that his near-death experience gave him insights which would be invaluable to younger pilots. He was denied until the outbreak of World War II created a demand for pilots. Accepted, he became a flying ace over France, during which time he destroyed one airplane due to his error when attempting a takeoff. Despite suffering an ugly head wound, Bader continued to fly, rising to the rank of Wing Commander.
Douglas Bader fought in the Battle of Britain and became one of the RAF’s most successful pilots before being shot down and captured by the Germans. Despite the handicap of two artificial legs, his numerous escape attempts so annoyed the Nazis that he was sent to the allegedly escape-proof Colditz Castle, where he remained until the war ended. Once freed, he returned to the Royal Air Force and lived to a sprightly 72.
On Second Thought…
Sometimes, the idea is interesting but the execution has faulty pistons. The startup Nectome was interested in preserving the brain’s “connectome” (all its memories and connections) by using a high-tech embalming fluid. Trouble is, their process is 100% fatal since it must be performed on a living brain to ensure perfect preservation for future digital uploading. As Emily Littela used to tell us, “never mind!”
Theoretical research suggests that an observer falling into a Schwartschild Black Hole could technically delay their inevitable death at the singularity by using a “momentary impulse” or “kick” from an engine. The traveler still dies, but this strategy maximizes his “proper time”---the subjective amount of life he experiences before hitting the center. Sorry researchers, nobody is paying any attention to your billboards.
Future medical concepts include nanorobots that crawl through blood vessels to manually destroy arterial plaque. By clearing blockages without invasive surgery, these microscopic machines could theoretically act as a human life snooze-button, delaying death from heart attacks or strokes indefinitely. But what if a nanobot or two goes rogue and decides to blackmail a subject in quest of a dacha on the Black Sea?
Medical professionals often observe patients who appear to wait for a specific event, such as a loved one’s arrival or a particular birthday or a Grand Finale before passing away. This is attributed to the intense conscious effort required to maintain breathing during terminal illness; once the will is satisfied and “Happy Trails” comes across the Heartwood sound system the happy camper finally lets go. Let’s hope it’s back at the hotel or the management won’t let us come back any more.
Some old-timers swear by lizard avoidance. You must never let a lizard count your teeth or it’s curtains. The ancients also thought you should turn over a shoe under the bed if you heard a dog howl at night. And then there is the old favorite, making a deal with the devil, like Dorian Grey and Donald Trump did. We all know what happened to Dorian, and our embedded D.C. reporters tell us the dreaded Tumbu flies are busily coalescing on the muddy banks of the Potomac.
That’s all, folks….